With the construction of UHV power grid, influences of bus arrangement systems applied in UHV substations on the reliability of the entire power grid have become more and more important. Therefore, the coordinated development between bus arrangement and power grid is a key to the design of UHV substations. This paper comprehensively analyzed the interplay between bus arrangement and power grid in terms of various network structures such as single-chain type, single-loop type and grid type; various locations of substations such as source end, receiving end and hub; and point-to-grid and point-to-point connection methods from UHV substations to the 500 kV power grid. Finally, design principles for UHV substations were proposed based on the analytical results, which is helpful to the selection of suitable bus arrangement systems for UHV substations.