Based on the local non-uniform section steel column of the conventional island in Taishan nuclear power plant, experiments of three specimen columns with 1 to 5 proportion subjected to eccentric load are carried out to study the failure mode, strain, deformation and bearing capacity. It is shown that the large slope or abrupt change of section has detrimental effects on the eccentric compression performance, leading to the reduction of the yield load and increase of the deformation. Furthermore, local strengthening has little impact on improving mechanical behavior. It could provide a reference for the design of similar structural components.