Conductor selection is an important link in designing large-crossing transmission project. In this paper, the characteristics of KTACSR/EST conductor and its application in large-crossing transmission projects are introduced. Taking a new-built large-crossing transmission project in Guangdong province as an example, the technical and economic comparison of different kinds of conductors are carried out. It is shown that the KTACSR/EST conductor can reduce the wind load of the tower and the investment of project effectively.