According to problems occurring in the process design for the cross-flow natural draft cooling tower, the improvement measures are put forward including the key equipment structures, simulated calculation approach, freeze-proofing and reductions in noise et al. Furthermore, the technical and economic analysis is carried out for the application of large cross-flow cooling tower on the nuclear power station. It is concluded that the cross-flow cooling tower applied in the nuclear power plant is feasible, of which the advantage is particularly evident in the large nuclear unit.