Coal breaker room, the largest and most complicated transfer station, is the difficulty for the design and layout of coal handling system in thermal power plant. However, the layout schemes of roller screen and coal breaker are the key point in designing the structure of coal breaker room, for avoiding the waste of space and increase of investment costs. According to the building area, storey height design and investment costs of coal breaker room, the parallel and stagger layout of roller screen and coal breaker are compared. It is found that the stagger layout is optimal.