This paper investigated the piping-block modular construction technology in CPR1000 nuclear power plants, discussed the selected principle and design process of the piping-block module, and developed the design function for the piping-block module using 3D platform, based on the successful experience of this technology used in foreign countries. The technical conditions were suggested for the implementation of piping-block module, which could provide a reference for the application of modular construction in the construction of CPR1000 nuclear power plants.