The comprehensive gallery of CPR 1000 nuclear power plant had already become an important influence factor of plant construction cost and schedule, due to the features of large scale, various interfaces and complex design cooperation. This paper introduced the design scope and content of gallery, pointed out the shortcomings of the traditional design method, chose the best combination mode of design schemes. The comparison selection and practical application prove that the method combined with detail type body design and active interface design is a strong practical optimized design method relative to previous conservative methods, because it can effectively optimize the arrangement of gallery to control construction cost, and improve the interface design efficiency to ensure construction schedule.