Large cooling towers are the typical wind sensitive structures. According to the characteristics of multiple coupling effect of wind induced responses, multimode and multiple equivalent objectives, mean wind loads and dominating vibration modes were selected as the basic vectors to express equivalent static wind loads for multiple objectives, and a constrained least squares method was applied for calculating the optimal combination factors of these basic vectors, in order to obtain multi-objective equivalent static wind loading. The advantage of the method is that equivalent static wind loads could reduce the dimension of equivalent static wind loading vector and to exclude some unrealistic and curious load distributions, and reflect the characteristics of wind-induced response. Combined with a wind tunnel test of large cooling towers in a nuclear power plant, the multi-objective equivalent static wind loading was analyzed for three groups of different equivalent targets’ structural response. The results show that the wind induced response under multi-objective equivalent static wind loading agrees well with the peak values under the actual dynamic wind loads.