Single factor analysis method has been commonly used for sensitivity analysis in economic decision, which is not completely correspondent with the actual situation, so multi-factor sensitivity analysis is proposed for financial net present value (FNPV). In this paper, sensitivity coefficients and boundary conditions of FNPV to various factors are analyzed firstly, and then the uncertainty of FNPV under multivariate changes is calculated and discussed with specific examples, which could provide references to investment decision and present measures for risk prevention.