The industrialization management of project design for nuclear power plants is very mature at abroad, while this work in China has just started. Withintroducing the features of foreign design industrialization management in this paper, the industrialization management of pipeline design for nuclear power plants adapted to China is proposed, including the design stage division and design control. Through the analysis of the efficiency and cost of industrialization management for pipeline design, the labor cost with the management pattern of industrialized thinning division is much smaller than that using the normal management pattern.