The great earthquake of M_S 8.0 occurring in Wenchuan County, Sichuan Province on May 12, 2008 has made serious impact on the normal operation of Sichuan Power Grid, which damaged numerous substation equipments and led to outages of substations. On the basis of an investigation on the substation damages incurred by the earthquake, the damage causes of electrical equipments and structures of substations are analyzed and the main anti-seismic design principle and suggestions are proposed. The anti-seismic calculation of the main transformer in a 750 kV substation located in the intensity Ⅷ area shows that the main electrical equipments of substations in high seismic area are prone to be damaged. Therefore, it is proposed that the link mode between equipment and their foundation or supporting frames (cantilevers) should be determined by calculations, and the equipment with good anti-seismic capabilities should be choosed in advance according to the project’s practical needs, so as to improve the anti-seismic capability of substations and meet the requirement of no-damage under light earthquake and no-collapse under strong earthquake.