The 1 000 kV structural gantry is a high and heavy load steel latticed structure, which is of vital importance in the 1 000 kV electric substation. The 1 000 kV structural gantry is a tall and slender structure and of high natural vibration period, therefore, its dynamic response under the action of wind load is very significant. This paper describes the simulation of the fluctuating wind speed in atmospheric boundary layer in Matlab by adapting the Davenport spectrum. The 1 000 kV structural gantry’s wind-induced response is analyzed in Ansys software on the premise that the wind is loaded on the structure. Then the wind-induced vibration coefficient is calculated on each subsection of the 1 000 kV structural gantry and compared with the design value based on the related regulations. The calculation results show that the wind-induced response of the 1 000 kV structural gantry in x direction is not exactly the same as that in y direction. The wind-induced vibration coefficient, which is obtained from the theoretical calculation, is not proportional to the height. The x direction wind-induced vibration coefficient mutated at the cross beam position. The member force calculation indicates that it is feasible to use a unified wind-induced vibration coefficient along the latticed section’s full height in the design of 1 000 kV structural gantry. The result is not different from the member force calculation based on the actual wind-induced vibration coefficient on each subsection.